Fig. 1

Heat shock response in LCLs. a Volcano plot showing differentially expressed genes following heat shock (42 °C for 1 h with 6 h recovery) in LCLs. Probes with an adjusted p value below 0.01 and a log FC of at least 0.5 are shown as yellow and red dots. Probes showing particularly strong evidence of changes in gene expression through a combination of p value and FC are labelled with the corresponding gene symbol. b Heatmap comparing gene expression for differentially expressed genes between basal and stimulated samples. Samples were clustered by gene with heat shocked (red) and basal (blue) samples forming two distinct groups. Expression estimates for each gene were scaled and centred across samples. Blue cells correspond to lower than average expression and red cells correspond to higher than average expression