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Fig. 2 | Genome Medicine

Fig. 2

From: Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series

Fig. 2

Adipose tissue metabotyping of congenic strains and haplotype-based metabotype mapping. 1H NMR spectra obtained at 600 MHz from adipose tissue extracts of the congenic strains and the BN controls (a) were used to map significant correlation networks (P < 0.05) between strains and metabolites in order to attach strain specific metabolite patterns (b) and identify chromosomal regions likely to contain GK variants responsible for variations in metabolite abundance (c) based on a barcode-type scoring for presence or absence of GK haplotypes. Blue bars represent the GK genomic segments of chromosome 1 of each congenic introgressed onto the genetic background of the BN strain. Genomic regions (R01–R16) were defined by coding the presence (1) or absence (0) of GK genotypes. Red squares indicate increased metabolite abundance and green squares increased metabolite level for each congenic strain and genomic region. Details of GK chromosomal regions introgressed in each congenic are given in Table 1. Sample numbers for each strain: BN (n = 5), 1cons (n = 4), 1b (n = 6), 1d (n = 4), 1f (n = 4), 1h (n = 4), 1k (n = 4), 1o (n = 6), 1p (n = 4), 1q (n = 5), 1t (n = 5), 1u (n = 6), 1v (n = 5)

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