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Fig. 4 | Genome Medicine

Fig. 4

From: Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series

Fig. 4

Network topological analysis of genetically regulated transcripts and metabotypes. a Summary of adipose transcripts and metabotypes associated with genomic regions using joint eQTL and mQTL mapping. b Mapping of mQTL-responsive metabolites and eQTL-responsive genes on an adipose-specific metabolic network. c Biologically relevant relationships between mQTL-responsive metabolites and eQTL-responsive transcripts highlighted by ranking of shortest path lengths across the metabolic network between gene–metabolite pairs (Additional file 3: Table S5). d Null distribution of average shortest path lengths obtained after 10,000 permutations consisting of a random selection of 20 metabolites and 73 reactions. The Asns enzyme has two catalytic sites for two reactions, which are identified as Asns-A and Asns-B in this figure

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