Fig. 5

Brain regions rank-ordered by the relevance to AD pathology. a Brain regions rank-ordered by the number of DEGs and TCGs with respect to six cognitive/neuropathological traits. From outside to inside, the bar chart in the first track shows the scaled ranking scores with the bar height proportional to the ranking score, the heat maps in tracks 2–7 show the ranking of regions by the number of DEGs between high and normal severity groups with respect to the traits CDR, Braak, CERAD, plaque density mean, sum of NP density estimates, and sum of NFT density estimates, respectively; the heat maps in tracks 8–13 show the ranking of regions by the number of TCGs for traits CDR, Braak, CERAD, plaque density mean, sum of NP density estimates, and sum of NFT density estimates, respectively; while the size and color intensity of the ribbons in the center show the number of correlated gene pairs at FDR < 0.05 between any two brain regions. The legend color intensity shows the number of DEGs/TCGs with respect to a trait at log scale. b The locations of the top ranked brain regions in (a) are highlighted by a dotted line