Fig. 7
The top 50 ranked modules in the co-expression networks of the 19 brain regions. From outside to inside, the bar chart at track 1 shows scaled ranking scores, the heat maps at tracks 2–7 show the correlation coefficients (r) between module eigengenes and six cognitive/neuropathological traits (in the order of CDR, Braak, CERAD, mean plaque density, sum of NP density estimates, and sum of NFT density estimates), the heat maps at tracks 8–13 show − log 10(P value) of the enrichment for the DEGs identified for the six traits, the –at tracks 14–19 show − log 10(P value) of the enrichment for the genes correlated with the six traits, and the links in the middle illustrate the significant correlations (FDR < 0.05; red for correlation > 0.8, blue for correlation < -0.8) among the modules