Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Table 1 The 20 top ranked modules

Region	Module	Top GO annotation term	Cell type specificity	Risk genes enrich.^a	Score	Rank
BM44-IFG	Yellow	Nucleus	Astrocytes	IGAP	1	1
BM20-ITG	Tan	Actin cytoskeleton	Oligodendrocytes	Aβ	0.89	2
BM44-IFG	Blue	Cytoplasm	Neurons	IGAP, Aβ	0.62	3
BM20-ITG	Red2	Positive regulation of transcription from RNA polymerase II promoter		-	0.6	4
BM36-PHG	Orchid	Cytoskeleton organization and biogenesis	-	-	0.56	5
BM8-SFG	Salmon	Cytoplasm	-	IGAP, Aβ	0.51	6
BM20-ITG	Mediumblue	Regulation of transcription DNA dependent	-	-	0.5	7
BM7-SPL	Brown	Nucleus	Astrocytes	IGAP	0.5	8
BM32-AC	Purple	Biopolymer metabolic process	-	IGAP	0.46	9
BM8-SFG	Blue	Membrane	Neurons	IGAP, Aβ	0.46	10
BM7-SPL	Gray17	Axon guidance	-	-	0.43	11
PT	Tan	Nervous system development	Neurons	IGAP	0.43	12
BM20-ITG	Maroon	Glycoprotein catabolic process	-	Aβ	0.4	13
BM8-SFG	Green	Nucleus	-	IGAP	0.39	14
BM20-ITG	Yellow2	Synaptogenesis	-	-	0.39	15
BM8-SFG	Pink	Nuclear part	Neurons	Aβ	0.39	16
BM20-ITG	Navy	Positive regulation of cell differentiation	Astrocytes	-	0.38	17
BM17-OVC	Brown	Nucleus	Neurons	IGAP, Aβ	0.38	18
BM4-PCG	Gray24	Regulation of transcription	-	-	0.38	19
PT	Yellow	Macromolecular complex	Neurons	IGAP, Aβ	0.37	20

ISSN: 1756-994X