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Fig. 1 | Genome Medicine

Fig. 1

From: Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

Fig. 1

Distribution of methylated CpG sites in HGSOC primary tumors and three generations of their corresponding PDX tumors. a β values are grouped in 0.1 increments and the percentage of probes is represented for each sample type (from patients (F0) to third generation PDX tumors (F3)). The mean β value for each sample type is shown between parentheses. Lowly, partially and highly methylated sites are indicated as LMS, PMS, and HMS, respectively. bd DNA methylation level of each sample type according to the genomic compartment (b), CpG context (c) and CpG island (CGI) content (d). Each bar represents mean DNA methylation β value ± SD; *p < 0.01. e Unsupervised clustering dendrogram showing the relationship of CpG probes between all the sample types. f The number of significant CpG sites in comparison with different sample types and their percentage compared to total CpG sites analyzed

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