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Fig. 2 | Genome Medicine

Fig. 2

From: Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

Fig. 2

Distribution of methylated CpG sites in HGSOC PDX tumors treated with decitabine (DAC) and cisplatin. a β-values are grouped in 0.1 increments and the percentage of probes is represented for each treatment group. The mean β value for each treatment group is shown between parentheses. Lowly, partially and highly methylated sites are indicated as LMS, PMS, and HMS, respectively. b–d DNA methylation level of each treatment group according to the genomic compartment (b), CpG context (c), and CpG island (CGI) content (d). Each bar represents mean DNA methylation β value ± SD. A Student’s t-test was performed compared to vehicle treated PDX tumors (F0); *p < 0.01. e Unsupervised clustering dendrogram showing the relationship of CpG probes between all the treatment groups. f Significant CpG sites in comparison with different sample types and their percentage compared to total CpG sites analyzed. g Supervised clustering analysis of significantly changed CpG sites (p < 0.01) in PDX-36 treated with DAC compared to vehicle-treated controls (n = 3 mice in each group)

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Genome Medicine

ISSN: 1756-994X

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