Skip to main content
Fig. 3 | Genome Medicine

Fig. 3

From: Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

Fig. 3

Identification of putative epigenetically regulated key genes and pathways related to ovarian cancer using PDX tumors. a Systematic strategy to identify CpG sites of novel putative epigenetically regulated genes. b Gene ontology terms enriched for biological processes using the candidate genes identified in the systematic strategy (n = 822). c Interactive functional association network based on predictive gene function and pathways using the same candidate genes (n = 822) by GeneMania (http://www.genemania.org/). Blue lines indicate related pathway connection; orange lines represent predicted interactions and red lines physical interactions. d Verification of seven DAC-affected genes using bisulfite pyrosequencing. Mean methylation (%) ± SD of respective genes for different analyzed CpG sites; *p < 0.05, **p < 0.01

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us