Table 1 The contribution of genomic information to precision cancer medicine
From: Integrating precision cancer medicine into healthcare—policy, practice, and research challenges
The contribution of genomic information to precision cancer medicine | Typical example(s) |
|---|---|
Cancer risk reduction | Genetic testing of BRCA1/BRCA2 in hereditary breast cancer and ovarian cancer; MSH2/MSH6/MLH in hereditary nonpolyposis colorectal cancer; RB1 in retinoblastoma |
Early detection | Liquid biopsies |
Accurate diagnosis | Using molecular markers in tumor classification |
Targeted therapy | EGFR inhibitors to treat EGFR mutation carriers; BRAF inhibitors to treat BRAF V600E carriers; Tyrosine-kinase inhibitor to treat BCR–ABL fusion protein |