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Table 3 Genotype-matched clinical trials by drug class, somatic genotypes (variant level), and tumor type (n = 89)

From: Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

Tumor type

Somatic genotype (variant)

Genotype-matching trial drug class

Target lesion percent change

Colorectal

No mutations (KRAS wildtype)

EGFR

−100 %

Breast

PIK3CA E545K

PI3K, Endocrine

−90 %

Colorectal

BRAF V600E

BRAF, PI3K, EGFR

−85 %

Colorectal

BRAF V600E

BRAF, PI3K, EGFR

−81 %

TP53 S215G

Gynecological

KRAS G13D

PI3K, MEK

−70 %

Gynecological

PIK3CA H1047R

VEGF

−64 %

KRAS G12D

Gynecological

KRAS G12V

PI3K, MEK

−63 %

Breast

PIK3CA H1047R

PI3K, IGF1R

−61 %

Lung

EGFR E746_A750del

EGFR

−58 %

EGFR T790M

Lung

KRAS G13D

MEK

−54 %

Breast

PIK3CA H1047R

PI3K

−50 %

Lung

EGFR L858R

EGFR

−47 %

EGFR T790M

CTNNB1 S37C

Gynecological

KRAS G12D

MEK

−47 %

Gynecological

KRAS G12V

PI3K, IGF1R

−45 %

NRAS Q61R

Gynecological

KRAS G12A

PI3K, MEK

−38 %

Breast

PIK3CA N345K

ANG2, MTOR

−37 %

Lung

KRAS G12D

PI3K, MEK

−37 %

Gynecological

PIK3CA H1047R

PI3K, MEK

−37 %

KRAS G12D

Lung

KRAS G12C

MEK

−28 %

Gynecological

TP53 K132N

WEE1

−26 %

Gynecological

KRAS G12D

PI3K, MEK

−25 %

Colorectal

BRAF V600E

BRAF, PI3K, EGFR

−24 %

TP53 R273C

PIK3CA Q546K

APC E1544X

Breast

ERBB2 D769H

HER2

−23 %

PIK3CA N345K

Upper aerodigestive

BRAF V600E

MEK

−20 %

Lung

KRAS G12S

MEK

−20 %

Gynecological

KRAS G12D

MEK, PI3K

−20 %

Colorectal

BRAF V600E

BRAF, PI3K, EGFR

−20 %

TP53 R175H

TP53 Q165X

Breast

FGFR2 Y376C

FGFR

−19 %

Breast

PIK3CA H1047L

PI3K

−18 %

Other

GNAQ Q209P

MEK

−18 %

Lung

EGFR L858R

HER3, EGFR

−18 %

Lung

KRAS G12A

PI3K, MEK

−17 %

Lung

EGFR L858R

HER3, EGFR

−17 %

Colorectal

KRAS G12D

PI3K, MEK

−16 %

PIK3CA E545K

Gynecological

KRAS G12V

PI3K, MEK

−16 %

Gynecological

BRAF V600E

MEK

−15 %

Gynecological

KRAS G12D

PI3K, MEK

−15 %

Lung

KRAS G12V

PI3K, MEK

−13 %

Colorectal

KRAS G12S

MEK, EGFR

−13 %

Gynecological

NRAS Q61K

PI3K, MEK

−13 %

Pancreatobiliary

KRAS G12V

PI3K, IGF1R

−13 %

Gynecological

PIK3CA H1047R

ANG2, mTOR

−9 %

Breast

PIK3CA E545K

AKT

−7 %

Colorectal

KRAS G12V

MEK, EGFR

−7 %

Breast

ERBB2 D769H

PI3K, IGF1R

−7 %

PIK3CA N345K

Lung

KRAS G12V

MEK

−6 %

Colorectal

ERBB2 L755S

VEGF, ANG2

−6 %

BRAF N581S

ERBB2 L755S

APC Q1429fs

Genitourinary

No mutations

PI3K

−5 %

PTEN negative on IHC

Lung

EGFR L858R

EGFR

−4 %

Lung

EGFR L858R

EGFR

−4 %

Lung

EGFR E746_A750del

EGFR

−3 %

Breast

PIK3CA H1047R

AKT

−3 %

Upper aerodigestive

KRAS G12V

PI3K, MEK

−2 %

Gynecological

KRAS G12D

PI3K, MEK

−2 %

Colorectal

KRAS G13D

MEK, EGFR

−0.6 %

Genitourinary

No mutations

PI3K

0 %

PTEN negative on IHC

Breast

PIK3CA H1047R

PI3K

0 %

Colorectal

PIK3CA E542K

PI3K

+0.5 %

KRAS G12V

Colorectal

No Mutations (KRAS wildtype)

MEK, EGFR

+2 %

Colorectal

KRAS G13D

PI3K, MEK

+2 %

PIK3CA E545K

Breast

PIK3CA H1047L

PI3K, IGF1R

+4 %

Genitourinary

No mutations

PI3K

+4 %

PTEN negative on IHC

Gynecological

PIK3CA E545K

MTOR

+5 %

Breast

PIK3CA N345K

PI3K, IGF1R

+6 %

Breast

PIK3CA N345K

PI3K, MEK

+6 %

NRAS G12D

Gynecological

PIK3CA C420R

FGFR, PI3K

+8 %

Colorectal

KRAS G12D

MEK, EGFR

+9 %

Lung

PIK3CA E545K

PI3K, IGF1R

+11 %

Colorectal

No mutations (KRAS wildtype)

MEK, EGFR

+11 %

Colorectal

KRAS G12D

PI3K, MEK

+12 %

PIK3CA Q546K

Gynecological

PIK3CA H1047R

PI3K, IGF1R

+12 %

Breast

PIK3CA p.Glu545Gly

AKT

+28 %

PTEN p.Leu320X

PIK3CA p.Arg93Gln

Gynecological

TP53 R175H

PI3K

+29 %

PIK3CA R93W

FBXW7 R479Q

Colorectal

KRAS G12D

PI3K, MEK

+30 %

PIK3CA E545K

Genitourinary

PIK3CA p.Asn345Lys

PI3K

+31 %

Breast

PIK3CA E545K

FGFR, PI3K

+32 %

Breast

PIK3CA H1047R

PI3K, IGF1R

+39 %

Colorectal

No mutations (KRAS wildtype)

MEK, EGFR

+55 %

Breast

PIK3CA E542K

PI3K, Endocrine

+66 %

Breast

PIK3CA N345K

PI3K, IGF1R

NE

Lung

KRAS G12C

PI3K, MEK

NE

Breast

PIK3CA H1047R

PI3K, IGF1R

NE

Lung

KRAS G12A

MEK

NE

PIK3CA H1047R

Gynecological

KRAS G12A

PI3K, IGF1R

NE

Breast

PIK3CA E545K

PI3K

NE

TP53 L252del

BRAF c.1315-4C > G

Gynecological

KRAS G12V

MEK

NE

Lung

BRAF V600E

MEK

NE

Breast

PIK3CA H1047L

PI3K

NE

TP53 C238Y

Other

KIT V559A

PI3K, EGFR

NE