Tumor type | Somatic genotype (variant) | Genotype-matching trial drug class | Target lesion percent change |
---|---|---|---|
Colorectal | No mutations (KRAS wildtype) | EGFR | −100 % |
Breast | PIK3CA E545K | PI3K, Endocrine | −90 % |
Colorectal | BRAF V600E | BRAF, PI3K, EGFR | −85 % |
Colorectal | BRAF V600E | BRAF, PI3K, EGFR | −81 % |
TP53 S215G | |||
Gynecological | KRAS G13D | PI3K, MEK | −70 % |
Gynecological | PIK3CA H1047R | VEGF | −64 % |
KRAS G12D | |||
Gynecological | KRAS G12V | PI3K, MEK | −63 % |
Breast | PIK3CA H1047R | PI3K, IGF1R | −61 % |
Lung | EGFR E746_A750del | EGFR | −58 % |
EGFR T790M | |||
Lung | KRAS G13D | MEK | −54 % |
Breast | PIK3CA H1047R | PI3K | −50 % |
Lung | EGFR L858R | EGFR | −47 % |
EGFR T790M | |||
CTNNB1 S37C | |||
Gynecological | KRAS G12D | MEK | −47 % |
Gynecological | KRAS G12V | PI3K, IGF1R | −45 % |
NRAS Q61R | |||
Gynecological | KRAS G12A | PI3K, MEK | −38 % |
Breast | PIK3CA N345K | ANG2, MTOR | −37 % |
Lung | KRAS G12D | PI3K, MEK | −37 % |
Gynecological | PIK3CA H1047R | PI3K, MEK | −37 % |
KRAS G12D | |||
Lung | KRAS G12C | MEK | −28 % |
Gynecological | TP53 K132N | WEE1 | −26 % |
Gynecological | KRAS G12D | PI3K, MEK | −25 % |
Colorectal | BRAF V600E | BRAF, PI3K, EGFR | −24 % |
TP53 R273C | |||
PIK3CA Q546K | |||
APC E1544X | |||
Breast | ERBB2 D769H | HER2 | −23 % |
PIK3CA N345K | |||
Upper aerodigestive | BRAF V600E | MEK | −20 % |
Lung | KRAS G12S | MEK | −20 % |
Gynecological | KRAS G12D | MEK, PI3K | −20 % |
Colorectal | BRAF V600E | BRAF, PI3K, EGFR | −20 % |
TP53 R175H | |||
TP53 Q165X | |||
Breast | FGFR2 Y376C | FGFR | −19 % |
Breast | PIK3CA H1047L | PI3K | −18 % |
Other | GNAQ Q209P | MEK | −18 % |
Lung | EGFR L858R | HER3, EGFR | −18 % |
Lung | KRAS G12A | PI3K, MEK | −17 % |
Lung | EGFR L858R | HER3, EGFR | −17 % |
Colorectal | KRAS G12D | PI3K, MEK | −16 % |
PIK3CA E545K | |||
Gynecological | KRAS G12V | PI3K, MEK | −16 % |
Gynecological | BRAF V600E | MEK | −15 % |
Gynecological | KRAS G12D | PI3K, MEK | −15 % |
Lung | KRAS G12V | PI3K, MEK | −13 % |
Colorectal | KRAS G12S | MEK, EGFR | −13 % |
Gynecological | NRAS Q61K | PI3K, MEK | −13 % |
Pancreatobiliary | KRAS G12V | PI3K, IGF1R | −13 % |
Gynecological | PIK3CA H1047R | ANG2, mTOR | −9 % |
Breast | PIK3CA E545K | AKT | −7 % |
Colorectal | KRAS G12V | MEK, EGFR | −7 % |
Breast | ERBB2 D769H | PI3K, IGF1R | −7 % |
PIK3CA N345K | |||
Lung | KRAS G12V | MEK | −6 % |
Colorectal | ERBB2 L755S | VEGF, ANG2 | −6 % |
BRAF N581S | |||
ERBB2 L755S | |||
APC Q1429fs | |||
Genitourinary | No mutations | PI3K | −5 % |
PTEN negative on IHC | |||
Lung | EGFR L858R | EGFR | −4 % |
Lung | EGFR L858R | EGFR | −4 % |
Lung | EGFR E746_A750del | EGFR | −3 % |
Breast | PIK3CA H1047R | AKT | −3 % |
Upper aerodigestive | KRAS G12V | PI3K, MEK | −2 % |
Gynecological | KRAS G12D | PI3K, MEK | −2 % |
Colorectal | KRAS G13D | MEK, EGFR | −0.6 % |
Genitourinary | No mutations | PI3K | 0 % |
PTEN negative on IHC | |||
Breast | PIK3CA H1047R | PI3K | 0 % |
Colorectal | PIK3CA E542K | PI3K | +0.5 % |
KRAS G12V | |||
Colorectal | No Mutations (KRAS wildtype) | MEK, EGFR | +2 % |
Colorectal | KRAS G13D | PI3K, MEK | +2 % |
PIK3CA E545K | |||
Breast | PIK3CA H1047L | PI3K, IGF1R | +4 % |
Genitourinary | No mutations | PI3K | +4 % |
PTEN negative on IHC | |||
Gynecological | PIK3CA E545K | MTOR | +5 % |
Breast | PIK3CA N345K | PI3K, IGF1R | +6 % |
Breast | PIK3CA N345K | PI3K, MEK | +6 % |
NRAS G12D | |||
Gynecological | PIK3CA C420R | FGFR, PI3K | +8 % |
Colorectal | KRAS G12D | MEK, EGFR | +9 % |
Lung | PIK3CA E545K | PI3K, IGF1R | +11 % |
Colorectal | No mutations (KRAS wildtype) | MEK, EGFR | +11 % |
Colorectal | KRAS G12D | PI3K, MEK | +12 % |
PIK3CA Q546K | |||
Gynecological | PIK3CA H1047R | PI3K, IGF1R | +12 % |
Breast | PIK3CA p.Glu545Gly | AKT | +28 % |
PTEN p.Leu320X | |||
PIK3CA p.Arg93Gln | |||
Gynecological | TP53 R175H | PI3K | +29 % |
PIK3CA R93W | |||
FBXW7 R479Q | |||
Colorectal | KRAS G12D | PI3K, MEK | +30 % |
PIK3CA E545K | |||
Genitourinary | PIK3CA p.Asn345Lys | PI3K | +31 % |
Breast | PIK3CA E545K | FGFR, PI3K | +32 % |
Breast | PIK3CA H1047R | PI3K, IGF1R | +39 % |
Colorectal | No mutations (KRAS wildtype) | MEK, EGFR | +55 % |
Breast | PIK3CA E542K | PI3K, Endocrine | +66 % |
Breast | PIK3CA N345K | PI3K, IGF1R | NE |
Lung | KRAS G12C | PI3K, MEK | NE |
Breast | PIK3CA H1047R | PI3K, IGF1R | NE |
Lung | KRAS G12A | MEK | NE |
PIK3CA H1047R | |||
Gynecological | KRAS G12A | PI3K, IGF1R | NE |
Breast | PIK3CA E545K | PI3K | NE |
TP53 L252del | |||
BRAF c.1315-4C > G | |||
Gynecological | KRAS G12V | MEK | NE |
Lung | BRAF V600E | MEK | NE |
Breast | PIK3CA H1047L | PI3K | NE |
TP53 C238Y | |||
Other | KIT V559A | PI3K, EGFR | NE |