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Table 3 Significant bacterial genera between benign and endometrial cancer cohorts

From: Potential contribution of the uterine microbiome in the development of endometrial cancer

Combined q < 0.10

Value

Standard error

Degrees of freedom

t value

p value

q value

Test

Firmicutes; Anaerostipes

3.4

0.795

25

4.3

0.0002

0.017

Presence/absence

Firmicutes; ph2

3.1

0.829

25

3.7

0.0010

0.031

Presence/absence

Spirochaetes; Treponema

3.9

1.066

25

3.7

0.0011

0.031

Presence/absence

Actinobacteria; Atopobium

2.5

0.707

25

3.5

0.0017

0.036

Presence/absence

Bacteroidetes; Bacteroides

1.1

0.332

25

3.3

0.0026

0.044

Counts

Proteobacteria; Arthrospira

3.6

1.150

25

3.1

0.0044

0.062

Presence/absence

Firmicutes; Dialister

1.2

0.405

25

3.0

0.0061

0.073

Presence/absence

Firmicutes; Peptoniphilus

1.4

0.494

25

2.9

0.0074

0.075

Presence/absence

Firmicutes; 1-68

1.3

0.465

25

2.9

0.0080

0.075

Presence/absence

Firmicutes; Ruminococcus

0.9

0.319

25

2.8

0.0109

0.082

Counts

Bacteroidetes; Porphyromonas

1.8

0.664

25

2.7

0.0111

0.082

Presence/absence

Firmicutes; Anaerotruncus

1.3

0.477

25

2.7

0.0117

0.082

Presence/absence

  1. Significant bacterial genera between benign and endometrial cancer cohorts in the vaginal, cervical, and endometrial microbiome as determined by generalized mixed effect model (FDR q < 0.10). All genera are enriched in the endometrial cancer cohort