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Table 3 Terminology systems that uniquely identify the genomically targeted antineoplastic drug vemurafeniba

From: Integrating cancer genomic data into electronic health records

Terminology short name Terminology long name (if applicable) Definition Unique code Website
ATC Anatomical Therapeutic Chemical classification system vemurafenib L01XE15 http://www.whocc.no/atc_ddd_index/
CAS Registry Number Chemical Abstracts Service Registry Number vemurafenib 918504-65-1 http://ww.cas.org/content/chemical-substances
ChEBI Chemical Entities of Biological Interest vemurafenib CHEBI:63637 https://www.ebi.ac.uk/chebi/
ChEMBL   vemurafenib CHEMBL1229517 https://www.ebi.ac.uk/chembl/
ChemSpider   vemurafenib 24747352 http://www.chemspider.com
DrugBank   vemurafenib DB08881 http://www.drugbank.ca
eMolecules   vemurafenib 32176418 https://www.emolecules.com
FDA UNII Code Food and Drug Administration Unique Ingredient Identifier vemurafenib 207SMY3FQT https://fdasis.nlm.nih.gov/srs/srs.jsp
Guide to Pharmacology IUPHAR/BPS Guide to Pharmacology vemurafenib 5893 http://www.guidetopharmacology.org
InChI IUPAC International Chemical Identifier vemurafenib GPXBXXGIAQBQNI-UHFFFAOYSA-N https://iupac.org/who-we-are/divisions/division-details/inchi/
KEGG DRUG Kyoto Encyclopedia of Genes and Genomes vemurafenib D09996 http://www.genome.jp/kegg/drug/
MeSH Medical Subject Headings PLX4032 C551177 https://www.ncbi.nlm.nih.gov/mesh
NCI Thesaurus National Cancer Institute Thesaurus vemurafenib C64768 https://ncit.nci.nih.gov/ncitbrowser/
NCI-GLOSS NCI Dictionary of Cancer Terms PLX4032 CDR0000670004 https://www.cancer.gov/publications/dictionaries/cancer-terms
PDBe Protein Data Bank in Europe PLX4032 32 http://www.ebi.ac.uk/pdbe/
PDQ Physician Data Query vemurafenib CDR0000528954 https://www.cancer.gov/publications/pdq
PubChem   vemurafenib CID:42611257 https://pubchem.ncbi.nlm.nih.gov
RxNorm   vemurafenib RxCUI:1147220 https://www.nlm.nih.gov/research/umls/rxnorm/
SNOMED-CT_US Systematized Nomenclature of Medicine - Clinical Terms, US Realm Vemurafenib (product) SCTID:703656005 https://www.nlm.nih.gov/healthit/snomedct/us_edition.html
UMLS Unified Medical Language System vemurafenib C1832009 https://www.nlm.nih.gov/research/umls/
ZINC   vemurafenib ZINC52509366 http://zinc15.docking.org
  1. aWhile these 21 distinct terminologies may not be exhaustive, they do illustrate the challenge of using terminology bindings in standards. Similar complexity is observed in terminologies for diseases, genes, proteins, and pathways (see Additional file 1)