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Fig. 1 | Genome Medicine

Fig. 1

From: Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Fig. 1

a Variation in Cl/F for the subjects who performed all three study days (SD) of the 50 mg talinolol study phase. b, c Correlation of the Cl/F after administration of 50 mg talinolol for all siblings from MZ (n = 42) and DZ (n = 13) twin pairs. d, e Correlation of the AUC7h after administration of 50 mg talinolol (filled circles) and the dose-adjusted AUC7h after administration of 2.5 mg talinolol (empty circles) for all analyzed twins. For b–d the Pearson correlation coefficients, the coefficients of determination, and the p-values are given. MZ monozygotic twin pairs, DZ dizygotic twin pairs, Cl/F total plasma clearance/bioavailability, AUC 7h area under the curve in the first 7 h after application, SD study day

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