Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Table 3 Heritability of talinolol pharmacokinetics (50 mg dose) according to the genetic component (rGC)

rGC genetic component, Cl/F total plasma clearance/bioavailability, AUC area under the curve, C _max maximum plasma concentration, t _max time of maximum plasma concentration, Vb variance between the subjects, Vw variance within each subject, 95 % CI 95 % confidence interval. The genetic component was calculated as rGC = (Vb − Vw)/Vb as proposed by Kalow [52, 53].

ISSN: 1756-994X