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Fig. 3 | Genome Medicine

Fig. 3

From: High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis

Fig. 3

DMR1, from TS1 after cell proportion correction, at the promoter region of PCDHB14 (chr5 140582954–140584018). DMR denotes the DMR location (grey box); CpGdens denotes CpG density as computed by CHARM [27] (CpG); CGI denotes the location of CpG islands (black box). TS1 Δbeta and TS2 Δbeta shows the smoothed linear slope (differences in methylation or delta) associated with ACPA-positive healthy and ACPA-positive RA twin, respectively, in the linear model which is used CHARM [27] to identify DMR candidates. Every point denotes a probe location. The location of the gene PCDHB14 is shown in a dotted box; the black square on the left denotes the location of the transcription start site

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