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Table 1 A summary of XGR characteristics for tasks achieved and runtime required

From: XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits

Functions

Tasks achieved

Runtimea

Enrichment analysis

 xEnricher

A template for enrichment analysis

~40

 xEnricherGenes

Gene-based enrichment analysis using a wide variety of ontologiesb

~40

 xEnricherSNPs

SNP-based enrichment analysis using Experimental Factor Ontology on GWAS traits

~70

 xEnricherYours

Custom-based enrichment analysis using user-defined ontologies

~5

 xEnrichConciser

Removing redundant ones from enrichment outputs

~15

 xEnrichBarplot

Barplot of enrichment outputs

<1

 xEnrichCompare

Side-by-side barplots of comparative enrichment outputs

<1

 xEnrichDAGplot

DAG plot of enrichment outputs

<1

 xEnrichDAGplotAdv

DAG plot of comparative enrichment outputs

<1

Annotation analysis

 xGRviaGeneAnno

Annotation analysis using nearby gene annotations by a wide variety of ontologiesb

~60

 xGRviaGenomicAnno

Annotation analysis using a wide variety of genomic annotationsc

~30

Similarity analysis

 xSocialiser

A template for similarity analysis

~60

 xSocialiserGenes

Gene-based similarity analysis using structured ontologies on functions, diseases, and phenotypes

~70

 xSocialiserSNPs

SNP-based similarity analysis using Experimental Factor Ontology on GWAS traits

~60

 xCircos

Circos plot of similarity outputs

~10

 xSocialiserDAGplot

DAG plot of one set of terms used for similarity analysis

<1

 xSocialiserDAGplotAdv

DAG plot of two sets of terms used for similarity analysis

<1

Network analysis

 xSubneterGenes

Gene-based network analysis

~60

 xSubneterSNPs

SNP-based network analysis

~60

 xVisNet

Network visualisation

<1

  1. aRuntime (measured by seconds) tested using one core on Mac OS X
  2. bIncluding structured ontologies on functions, diseases, and phenotypes, and non-structured ontologies on pathways, regulatory/expression signatures, druggability, structural domains, GTEx eGene tissues, others
  3. cIncluding genomic annotations sourced from ENCODE, FANTOME5, BLUEPRINT Epigenome, Roadmap Epigenomics, The Cancer Genome Atlas, UCSC, others