Fig. 3

Cluster of 26-gene co-mutation patterns. Cluster analysis was performed on non-hypermutated Japanese CRC samples (n = 184 tumors) by using Euclidean distance and Ward’s clustering method and co-mutation patterns of the 26-gene subset with statistical analysis are shown. Mutation rate in each group is shown as a bar graph in the middle panel. Group-based mean values for age and tumor diameter are shown (left) with cluster colors and fraction for clinical information (right). Dark bars indicate significant difference (p < 0.05, two-tailed Fisher’s exact test) to the distribution of all other non-hypermutated donors, light bars are non-significant (*p < 0.05, **p < 0.01). Chemo chemotherapy; Cmab Cetuximab; Pmab Panitumumab; Bmab Bevacizumab. ^†Combination therapy with other inhibitors (e.g. anti-EGFR, MEK inhibitors) will be recommended