iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

Table 1 Functionality comparison between iCAGES and other cancer driver gene detection tools. "V" represents "available"

Category	Sub category	Sub Subcategory	Output	Tool	VCF input format	Single patient analysis	Structural variation analysis	Web server	Personalized drug	Graphical result	Prior knowledge integration	Non-coding Variant
Genomic variant analysis tools	Batch analysis tools	Driver point mutation prioritization	Protein-coding drivers	CHASM		V		V
				Mutation Assessor		V		V
				FATHMM		V		V
				SIFT		V		V
				PolyPhen-2		V		V
				GERP++		V						V
				VEST	V	V		V
			Non-coding drivers	FunSeq2		V		V				V
		Driver gene prioritization		MuSiC			V					V
				MutSigCV			V	V				V
				Youn-Simon				V				V
	Personal analysis tools	Driver gene prioritization		iCAGES	V	V	V	V	V	V	V	V
				Phen-Gen	V	V		V			V
				OncoIMPACT		V	V
Transcriptomic expression analysis tools				PARADIGM-SHIFT			V
				DawnRank		V
				CONEXIC			V
				TieDIE
				DriverNet			V
				Memo			V				V
				Dendrix			V
Phosphorylation analysis tools				ActiveDriver								V

ISSN: 1756-994X