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Table 1 Functionality comparison between iCAGES and other cancer driver gene detection tools. "V" represents "available"

From: iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

Category Sub category Sub Subcategory Output Tool VCF input format Single patient analysis Structural variation analysis Web server Personalized drug Graphical result Prior knowledge integration Non-coding Variant
Genomic variant analysis tools Batch analysis tools Driver point mutation prioritization Protein-coding drivers CHASM   V   V     
Mutation Assessor   V   V     
FATHMM   V   V     
SIFT   V   V     
PolyPhen-2   V   V     
GERP++   V       V
VEST V V   V     
Non-coding drivers FunSeq2   V   V     V
Driver gene prioritization MuSiC    V      V
MutSigCV    V V     V
Youn-Simon     V     V
Personal analysis tools Driver gene prioritization iCAGES V V V V V V V V
Phen-Gen V V   V    V  
OncoIMPACT   V V      
Transcriptomic expression analysis tools PARADIGM-SHIFT    V      
DawnRank   V       
CONEXIC    V      
TieDIE         
DriverNet    V      
Memo    V     V  
Dendrix    V      
Phosphorylation analysis tools ActiveDriver         V