Table 1 Example 3D clusters with potential functional targets
From: 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Gene | PDB ID: chain | Position (number of mutated samples) | p | Cancer types (number of mutated samples)* |
|---|---|---|---|---|
EGFR | 1IVO:B | R252(8) F254(1) D256(2) K261(1) T263(2) C264(1) A289(28) | 0.016 | GBM(30) LGG(8) Stomach ADCA(2) Other(3) |
EGFR | 2JIU:B | V769(1) R831(2) R832(2) L833(2) L858(30) L861(7) H893(1) | 0.025 | Lung ADCA(39) Lung SCC(2) CRC(2) Other(2) |
KIT | 4HVS:A | W557(1) V559(3) V560(1) L576(2) | 0.085 | Melanoma(6) Stomach ADCA(1) |
MTOR | 4JT5:B | A1459(1) L1460(2) V1461(1) Y1463(1) K1465(1) M1467(1) R1480(2) C1483(5) | 0.035 | ccRCC(7) BRCA(1) CRC(1) Other(5) |
MTOR | 4JSN:A | A1971(3) I1973(2) Y1974(1) T1977(3) M1998(1) V2006(2) | 0.047 | ccRCC(4) CLL(2) Endometrial CA(2) Other(4) |
PIK3CA | 2v1y_A | R38(14) E39(5) R88(40) C90(4) R93(15) | 0.014 | Endometrial CA(27) CRC(19) Other(32) |
MAPK1 | 4FV5:A | E81(2) R135(1) G136(1) D321(3) E322(15) | 0.014 | Cervical SCC(9) HNC(9) BRCA(1) Other(3) |
FGFR3 | 1RY7:B | R248(9) S249(18) P250(1) D280(2) | 0.050 | Bladder CA(17) HNC(6) Lung SCC(3) Other(4) |