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Fig. 4 | Genome Medicine

Fig. 4

From: Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells

Fig. 4

Altered expression patterns of genes with disrupted coding sequences. Relative expression differences of disrupted genes a FOXP1 (NM_032682), b DPYD (NM_000110), c ETV1 (NM_001163152), and d HDAC9 (NM_001204144 and NM_178423) between the patient and parents in the iPSC-derived NPCs, iPSCs, and blood cells. Gene structures of the RefSeq transcripts described above are shown below the graphs. Vertical red lines indicate the breakpoint locations. Minus and plus signs indicate the DNA strand. Expression is not shown for fragments with less than ten normalized read counts in the patient or the parents

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