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Fig. 6 | Genome Medicine

Fig. 6

From: Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells

Fig. 6

Gains of genomic interactions on the derivative chromosomes of the patient. Hi-C chromatin interaction maps of the patient’s (cell line UMCU15, bottom panels) and father’s (cell line UMCU23, top panels) chromosome 7 (left panels) and derivative chromosome 3 (right panels). Interactions are shown at 100-kb resolution. The vertical black lines at the bases of the heatmaps depict the predicted TAD boundaries in hESCs as determined by Dixon et al. [38]. Vertical red lines between the interaction maps indicate the breakpoint locations in the patient

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