Fig. 2

Genomic profile of the presented case. a Circos plot representing the CNV status of the original GBM and two recurrences. The innermost circle represents the primary tumor, whereas the middle and outer-most circles depict the first and second recurrences, respectively (black, no event; blue, deletion; red, amplification). b IGV plot of the locus of the EGFR A289V mutation in three tumors and matching blood. All three tumors show amplification at the locus but only the primary tumor has supporting reads for variant A289V