Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Longitudinal analysis of treatment-induced genomic alterations in gliomas

Fig. 4

Cases with chromothripsis in the Yale-Glioma cohort. Circos plots of six GBM cases with chromothripsis (only affected chromosomes are plotted). The outer-most circles depict the chromosomes (numbers shown) and shift in lesser allele frequency (in orange), respectively. The next track plots the copy number status (black, no event; blue, deletion; red, amplification). Links in the inner track display the inter- or intra-chromosomal breaks. a A GBM with chromothripsis affecting chromosome (chr) 12 and chr7 with high level amplification and a large number of inter-chromosomal breaks. b Chr1–chr7 chromothripsis event with high level amplification. c Chr12–chr6 event with high level amplification and inter-chromosomal breaks. d Chr7–chr16 chromothripsis with high level of amplification. e Chr3–chr5 event causing deletion in secondary GBM case. f Chr12–chr20 deletion with inter-chromosomal breaks

Back to article page
\