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Fig. 5 | Genome Medicine

Fig. 5

From: Longitudinal analysis of treatment-induced genomic alterations in gliomas

Fig. 5

Clonal evolution and mutation signature analysis of the presented case. a Clonal evolution of the primary tumor, first recurrence and second recurrence. Nine unique somatic mutation clusters are identified. Whereas cluster 1 contains the high clonal somatic mutations that are preserved through the evolution of the tumor, cluster 8 represents mutations that are lost (or preserved with very low clonality) during recurrence. Interestingly, all the remaining clusters contain mutations that are unique to the second recurrence tumor, with the exception of mutations in cluster 6, which emerged during the first recurrence. b Mutational signatures of tumors reveal an increased burden of C to T alteration for the second recurrence due to acquired MMR deficiency. All mutational signatures are shown with the color codes explained at the bottom. c Distribution of somatic mutation signatures including the 5′ and 3′ flanking bases. The second recurrence has an increase in C > T alterations in addition to the hypermutated phenotype and displays a signature similar to the one induced by the alkylating agents [33]

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