Fig. 1
rs612529 is an eQTL affecting SIRL-1 expression. a Manhattan plot of whole blood eQTLs located in the SIRL-1-encoding VSTM1 gene region. The upper panel depicts the position of VSTM1 transcripts in relation to a CGI and the SNPs rs612529 and rs662850. The lower panel shows the eQTL-association determined from whole blood samples of 202 Chinese individuals. The P value (expressed as –log10) is displayed on the y-axis, the x-axis shows the location of the SNPs (rs612529 is indicated). b, c Genotype effect of rs612529 on the SIRL-1 mRNA expression monocytes and B cells. The data were generated from cohort samples of 15 Chinese [18] and 281 Caucasian individuals [19]. The number of individuals per genotype is indicated on the x-axis; the y-axis represents the SIRL-1 mRNA expression levels depicted as log2 value. d Allele frequencies of rs612529 in three major ethnical groups. The pie charts display the frequencies of the C allele (red) and the T allele (blue) for Caucasian, Han Chinese, and Japanese based on HapMap