Fig. 2
From: Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas
PCoA plots of weighted and unweighted UniFrac distances of tumor and normal samples. Overall oral microbiomic diversity of patient samples as represented by PCoA of weighted and unweighted UniFrac distances. In panel (a), each point represents a single tumor (orange square) or adjacent normal (blue circle) sample, with plus sign and ellipses (orange solid line = tumor, blue dashed line = normal) representing the fitted mean and 68% confidence interval of each group, respectively. Adonis testing revealed statistically significant clustering based on the tumor/normal grouping (weighted p = 0.012, unweighted p = 0.042), but this clustering only explained a small proportion of the overall variation among samples (weighted R2 = 0.010, unweighted R2 = 0.006). In panel (b), each point represents a single oral cavity/oropharyngeal (magenta) or hypopharyngeal/laryngeal (green) sample, with plus sign and ellipses (magenta solid line = oral cavity/oropharynx, green dashed line = hypopharynx/larynx) representing the fitted mean and 68% confidence interval of each group respectively. The different shapes provided by the legend delineate smaller sub-categories of each location. Adonis testing revealed statistically significant clustering of oral cavity/oropharyngeal samples relative to hypopharyngeal/laryngeal samples (weighted p = 0.001, unweighted p = 0.001), but this clustering only explained a small proportion of the overall variation among samples (weighted R2 = 0.018, unweighted R2 = 0.014)