Fig. 2

Temporal instability of microbiome community structure correlates with increasing abundance of pathogenic-associated genera over time. Heatmap of all samples and untransformed relative abundance values of indicated bacterial taxa colored white to red as denoted in the figure. Samples from each patient are clustered together and arranged by timepoint (i.e., consecutive samples) from left to right. Additionally, clusters of patient samples are organized in accordance with temporal variability as determined by the coefficient of variation of the weighted UniFrac distance (cv_w.unifrac) with increasing variability from left to right. Taxa are organized from top to bottom by highest positive correlation of relative abundance of genera with CV of the weighted UniFrac distance, to negative correlation as determined by Pearson’s correlation (r) values depicted in the colored inlaid figure legend. A P value for the correlation’s significance (Corr.SigLvl) was derived from the test statistic based on Pearson’s product moment correlation coefficient, corrected for multiple comparisons with the Benjamini and Hochberg method, and displayed on the plot