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Table 1 Breakdown of samples used for the identification of IVF-DMRs and potential covariates

From: DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation

Group Total number of twins (number of complete sets) Zygosity and chorionicitya Sexb Birth weight (kg): mean(sd) Maternal age (years): mean (sd) Maternal smoking (percentage smokers) Ovarian stimulation ICSI GIFT Frozen embryo
WBCs
IVF 40 (20) 10 MZ MC
30 DZ DC
18 (F)
22 (M)
2.57 (4.77) 36 (4) 20% 6 (No)
34 (Yes)
22 (No)
18 (Yes)
- 28 (No)
12 (Yes)
Non-IVF 58 (29) 14 MZ MC
12 MZ DC
32 DZ DC
34 (F)
24 (M)
2.58 (3.99) 32 (5) 28% 56 (No)
2 (Yes)
- 56 (No)
2 (Yes)
-
CBMCs
IVF 35 (16) 9 MZ MC
1 MZ DC
25 DZ DC
16 (F)
19 (M)
2.50 (4.42) 35 (5) 23% 1 (No)
34 (Yes)
14 (No)
21 (Yes)
- 24 (No)
11 (Yes)
Non-IVF 47 (22) 12 MZ MC
10 MZ DC
25 DZ DC
30 (F)
17 (M)
2.60 (3.48) 32 (4) 28% 45 (No)
2 (Yes)
- 45 (No)
2 (Yes)
-
  1. a MZ monozygotic, DZ dizygotic, MC monochorionic, DC dichorionic
  2. b F female, M male
  3. GIFT gamete intra-fallopian transfer, ICSI intracytoplasmic sperm injection, sd standard deviation