From: DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation
 |  |  | IVF (n = 40) versus non-IVF (n = 58) | IVF (n = 34) versus non-IVF (n = 58) adjusted for ICSI | Conventional IVF (n = 16) versus non-IVF (n = 58) | ICSI (n = 18) versus non-IVF (n = 58) | ||||||||
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Chromosome | Start | End | Estimate | SE | P | Estimate | SE | P | Estimate | SE | P | Estimate | SE | P |
Chr2 | 217726751 | 217727250 | 1.18 | 0.19 | 2.30E-09 | 1.45 | 0.26 | 7.71E-08 | −1.42 | 0.26 | 7.44E-08 | −1.16 | 0.27 | 1.29E-05 |
Chr5 | 178761751 | 178762250 | −1.08 | 0.2 | 5.43E-08 | −1.09 | 0.29 | 8.23E-05 | 0.87 | 0.30 | 1.89E-03 | 1.11 | 0.27 | 2.52E-05 |
Chr9 | 97504001 | 97504500 | 1.07 | 0.2 | 5.83E-08 | 0.77 | 0.27 | 2.77E-03 | −0.88 | 0.31 | 2.67E-03 | −1.30 | 0.25 | 1.95E-07 |
Chr5 | 9275751 | 9276250 | 1.09 | 0.19 | 5.86E-08 | 1.17 | 0.27 | 1.04E-05 | −1.13 | 0.29 | 6.50E-05 | −1.13 | 0.27 | 2.75E-05 |
Chr4 | 184814001 | 184814500 | −0.96 | 0.18 | 7.95E-08 | −0.97 | 0.24 | 3.94E-05 | 0.94 | 0.26 | 1.37E-04 | 1.15 | 0.23 | 8.35E-07 |
Chr5 | 142488501 | 142489000 | −1.11 | 0.2 | 8.73E-08 | −1.1 | 0.28 | 7.60E-05 | 1.25 | 0.31 | 5.16E-05 | 1.08 | 0.28 | 7.10E-05 |
Chr9 | 118148751 | 118149250 | 1.09 | 0.2 | 9.20E-08 | 1.35 | 0.28 | 1.28E-06 | −1.30 | 0.29 | 8.90E-06 | −1.02 | 0.28 | 1.68E-04 |
Chr9 | 118149001 | 118149500 | 1.08 | 0.2 | 1.04E-07 | 1.31 | 0.28 | 2.22E-06 | −1.23 | 0.29 | 2.00E-05 | −1.05 | 0.29 | 1.69E-04 |
Chr11 | 82654251 | 82654750 | −1.05 | 0.19 | 1.30E-07 | −0.97 | 0.29 | 4.68E-04 | 0.95 | 0.31 | 1.53E-03 | 0.88 | 0.27 | 5.94E-04 |
Chr19 | 6165251 | 6165750 | 0.94 | 0.18 | 1.40E-07 | 0.89 | 0.25 | 1.90E-04 | −0.88 | 0.28 | 9.35E-04 | −1.02 | 0.23 | 7.36E-06 |
Chr1 | 85522251 | 85522750 | 0.99 | 0.18 | 1.43E-07 | 1.54 | 0.25 | 4.48E-09 | −1.53 | 0.25 | 7.41E-09 | −0.80 | 0.28 | 2.32E-03 |
Chr17 | 42569001 | 42569500 | −1.07 | 0.19 | 1.64E-07 | −1.25 | 0.27 | 2.21E-06 | 1.30 | 0.28 | 3.81E-06 | 1.21 | 0.26 | 2.44E-06 |
Chr4 | 141606501 | 141607000 | 1.09 | 0.19 | 2.03E-07 | 1.26 | 0.26 | 3.56E-06 | −1.33 | 0.30 | 1.05E-05 | −1.13 | 0.26 | 1.83E-05 |
Chr5 | 137736001 | 137736500 | −1.03 | 0.19 | 2.06E-07 | −1.11 | 0.28 | 4.12E-05 | 1.13 | 0.30 | 1.39E-04 | 1.10 | 0.27 | 3.78E-05 |
Chr5 | 150614501 | 150615000 | −1.08 | 0.21 | 2.14E-07 | −1.2 | 0.29 | 2.80E-05 | 1.24 | 0.31 | 3.18E-05 | 1.07 | 0.29 | 1.21E-04 |
Chr17 | 36918251 | 36918750 | −1.1 | 0.21 | 2.32E-07 | −0.96 | 0.29 | 6.01E-04 | 1.05 | 0.31 | 4.88E-04 | 1.03 | 0.28 | 1.83E-04 |
Chr6 | 126138251 | 126138750 | −0.99 | 0.19 | 2.36E-07 | −0.75 | 0.27 | 3.29E-03 | 0.79 | 0.30 | 4.92E-03 | 1.22 | 0.25 | 8.94E-07 |
Chr7 | 144431251 | 144431750 | 1.02 | 0.19 | 2.70E-07 | 0.84 | 0.28 | 1.30E-03 | −0.85 | 0.28 | 1.48E-03 | −1.17 | 0.27 | 1.77E-05 |
Chr12 | 70937251 | 70937750 | 0.88 | 0.17 | 2.76E-07 | 0.72 | 0.23 | 1.12E-03 | −0.87 | 0.26 | 5.26E-04 | −0.94 | 0.20 | 3.10E-06 |
Chr4 | 141606251 | 141606750 | 1.01 | 0.19 | 2.80E-07 | 1.16 | 0.26 | 8.05E-06 | −1.31 | 0.29 | 6.93E-06 | −1.04 | 0.25 | 2.14E-05 |
Chr13 | 90019001 | 90019500 | 1.06 | 0.2 | 2.84E-07 | 1.25 | 0.29 | 8.88E-06 | −1.36 | 0.30 | 5.09E-06 | −0.84 | 0.29 | 2.20E-03 |
Chr11 | 74179001 | 74179500 | 1.07 | 0.2 | 2.92E-07 | 1.3 | 0.29 | 7.25E-06 | −1.37 | 0.29 | 3.15E-06 | −1.06 | 0.29 | 1.76E-04 |
Chr12 | 99153001 | 99153500 | −1.01 | 0.2 | 3.93E-07 | −1.02 | 0.29 | 2.02E-04 | 1.02 | 0.31 | 4.59E-04 | 1.24 | 0.27 | 3.77E-06 |
Chr2 | 223336751 | 223337250 | −1.01 | 0.2 | 4.47E-07 | −1.41 | 0.28 | 4.00E-07 | 1.50 | 0.29 | 1.69E-07 | 0.77 | 0.29 | 4.65E-03 |
Chr8 | 120972001 | 120972500 | 0.97 | 0.19 | 4.98E-07 | 0.83 | 0.27 | 1.22E-03 | −0.87 | 0.29 | 1.43E-03 | −0.96 | 0.26 | 1.81E-04 |
Chr17 | 38047001 | 38047500 | −1.04 | 0.2 | 5.25E-07 | −1.3 | 0.28 | 4.51E-06 | 1.31 | 0.27 | 1.21E-06 | 0.74 | 0.28 | 5.39E-03 |
Chr4 | 64626751 | 64627250 | −0.99 | 0.19 | 5.45E-07 | −0.87 | 0.28 | 9.92E-04 | 0.86 | 0.29 | 1.61E-03 | 0.98 | 0.26 | 1.36E-04 |
Chr16 | 87256751 | 87257250 | −0.83 | 0.16 | 5.51E-07 | −0.97 | 0.23 | 1.75E-05 | 0.94 | 0.25 | 9.13E-05 | 0.82 | 0.24 | 3.37E-04 |
Chr19 | 10656751 | 10657250 | −1.03 | 0.2 | 5.77E-07 | −1.09 | 0.28 | 6.47E-05 | 1.17 | 0.29 | 3.80E-05 | 1.13 | 0.27 | 2.18E-05 |
Chr7 | 2487251 | 2487750 | 0.8 | 0.16 | 5.85E-07 | 0.73 | 0.23 | 1.06E-03 | −0.81 | 0.24 | 5.61E-04 | −0.94 | 0.23 | 3.49E-05 |
Chr11 | 74178751 | 74179250 | 0.99 | 0.2 | 6.82E-07 | 1.19 | 0.28 | 2.15E-05 | −1.15 | 0.28 | 2.45E-05 | −0.82 | 0.28 | 2.37E-03 |
Chr10 | 119176501 | 119177000 | −1.04 | 0.2 | 6.87E-07 | −1.03 | 0.29 | 3.41E-04 | 1.16 | 0.31 | 1.69E-04 | 1.14 | 0.28 | 4.83E-05 |
Chr22 | 34755251 | 34755750 | −0.98 | 0.2 | 7.32E-07 | −0.8 | 0.28 | 2.35E-03 | 0.97 | 0.31 | 1.21E-03 | 1.15 | 0.25 | 3.95E-06 |
Chr6 | 161664751 | 161665250 | 0.98 | 0.19 | 7.42E-07 | 0.9 | 0.26 | 3.89E-04 | −0.83 | 0.29 | 2.48E-03 | −0.81 | 0.25 | 7.71E-04 |
Chr16 | 17161751 | 17162250 | −1.01 | 0.2 | 7.80E-07 | −0.99 | 0.28 | 2.19E-04 | 1.17 | 0.30 | 4.48E-05 | 1.08 | 0.28 | 1.16E-04 |
Chr18 | 23695001 | 23695500 | 1.04 | 0.21 | 8.39E-07 | 0.95 | 0.29 | 5.83E-04 | −1.04 | 0.32 | 6.05E-04 | −1.11 | 0.28 | 3.96E-05 |
Chr9 | 26364751 | 26365250 | −0.95 | 0.19 | 8.90E-07 | −0.96 | 0.28 | 2.78E-04 | 1.13 | 0.30 | 9.90E-05 | 0.96 | 0.28 | 2.77E-04 |
Chr1 | 25227001 | 25227500 | −0.83 | 0.17 | 9.05E-07 | −0.87 | 0.25 | 3.81E-04 | 0.78 | 0.25 | 1.39E-03 | 0.99 | 0.25 | 5.78E-05 |
Chr13 | 68877251 | 68877750 | 0.97 | 0.2 | 9.43E-07 | 1.01 | 0.28 | 1.44E-04 | −1.24 | 0.28 | 1.05E-05 | −0.84 | 0.28 | 1.39E-03 |
Chr9 | 89126501 | 89127000 | −0.92 | 0.19 | 9.59E-07 | −1.14 | 0.26 | 9.49E-06 | 1.10 | 0.28 | 6.62E-05 | 0.76 | 0.26 | 2.12E-03 |
Chr13 | 35317501 | 35318000 | −0.96 | 0.2 | 9.72E-07 | −0.54 | 0.29 | 4.44E-02 | 0.54 | 0.31 | 6.52E-02 | 1.04 | 0.27 | 7.61E-05 |
Chr21 | 19575001 | 19575500 | 0.96 | 0.19 | 9.92E-07 | 0.88 | 0.27 | 8.63E-04 | −0.96 | 0.30 | 8.25E-04 | −1.13 | 0.26 | 1.24E-05 |
Chr2 | 169470001 | 169470500 | −1.02 | 0.21 | 1.06E-06 | −1.31 | 0.28 | 2.08E-06 | 1.33 | 0.29 | 6.99E-06 | 1.04 | 0.27 | 5.91E-05 |
Chr12 | 4310251 | 4310750 | −0.99 | 0.2 | 1.06E-06 | −0.91 | 0.29 | 8.79E-04 | 1.02 | 0.30 | 4.54E-04 | 0.87 | 0.30 | 1.99E-03 |
Chr6 | 157136501 | 157137000 | −0.96 | 0.19 | 1.15E-06 | −0.78 | 0.27 | 2.19E-03 | 0.91 | 0.30 | 1.37E-03 | 1.30 | 0.25 | 1.62E-07 |
Chr14 | 104067251 | 104067750 | 0.71 | 0.14 | 1.17E-06 | 0.81 | 0.21 | 7.35E-05 | −0.75 | 0.22 | 3.89E-04 | −0.58 | 0.24 | 9.44E-03 |