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Table 3 Heart rate top hits

From: Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

Gene SNP Chr Position Effect allele GS minor allele frequency HRC MAF GS p value GS effect size GWAS catalog top SNP GWAS catalog p value GS and meta SNP R2 GS and meta SNP Dā€™
ICMT rs9970334 1 6296238 G 0.447 0.4502 4.38E-08 0.70 rs846111 7.00E-40 [51] 0.47 0.98
- rs755291044 3 87751558 A 0.002 - 1.80E-08 8.60 NA NA NA NA
CSMD1 rs145669495 8 4102424 G 0.002 0.0024 2.01E-08 7.66 NA NA NA NA
ASPH rs142916219 8 62481520 G 0.004 0.0022 2.21E-08 5.97 NA NA NA NA
MYH6 rs365990* 14 23861811 G 0.364 0.3644 4.04E-10 0.78 rs365990 5.00E-45 [52] 1 1
- rs148397504 20 5376623 A 0.001 0.0006 3.21E-09 18.54 NA NA NA NA
  1. Summary of top hits of the imputed GWAS analysis of heart rate in 19,920 Generation Scotland participants, compared with associations reported in the GWAS catalogue. The starred (*) SNP indicates the same SNP in the GS and GWAS catalogue. Entries in bold are within 500,000 bases of a SNP that reached genome-wide significance in the genotyped GWAS analysis. Entries with missing GWAS catalogue top SNPs (indicated by NAs) are novel associations