Table 3 Heart rate top hits
Gene | SNP | Chr | Position | Effect allele | GS minor allele frequency | HRC MAF | GS p value | GS effect size | GWAS catalog top SNP | GWAS catalog p value | GS and meta SNP R2 | GS and meta SNP D’ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ICMT | rs9970334 | 1 | 6296238 | G | 0.447 | 0.4502 | 4.38E-08 | 0.70 | rs846111 | 7.00E-40 [51] | 0.47 | 0.98 |
- | rs755291044 | 3 | 87751558 | A | 0.002 | - | 1.80E-08 | 8.60 | NA | NA | NA | NA |
CSMD1 | rs145669495 | 8 | 4102424 | G | 0.002 | 0.0024 | 2.01E-08 | 7.66 | NA | NA | NA | NA |
ASPH | rs142916219 | 8 | 62481520 | G | 0.004 | 0.0022 | 2.21E-08 | 5.97 | NA | NA | NA | NA |
MYH6 | rs365990* | 14 | 23861811 | G | 0.364 | 0.3644 | 4.04E-10 | 0.78 | rs365990 | 5.00E-45 [52] | 1 | 1 |
- | rs148397504 | 20 | 5376623 | A | 0.001 | 0.0006 | 3.21E-09 | 18.54 | NA | NA | NA | NA |