|
Gene
|
SNP
|
Chr
|
Position
|
Effect allele
|
GS minor allele frequency
|
HRC MAF
|
GS p value
|
GS effect size
|
GWAS catalog top SNP
|
GWAS catalog p value
|
GS and meta SNP R2
|
GS and meta SNP D’
|
|---|
|
ICMT
|
rs9970334
|
1
|
6296238
|
G
|
0.447
|
0.4502
|
4.38E-08
|
0.70
|
rs846111
|
7.00E-40 [51]
|
0.47
|
0.98
|
|
-
|
rs755291044
|
3
|
87751558
|
A
|
0.002
|
-
|
1.80E-08
|
8.60
|
NA
|
NA
|
NA
|
NA
|
|
CSMD1
|
rs145669495
|
8
|
4102424
|
G
|
0.002
|
0.0024
|
2.01E-08
|
7.66
|
NA
|
NA
|
NA
|
NA
|
|
ASPH
|
rs142916219
|
8
|
62481520
|
G
|
0.004
|
0.0022
|
2.21E-08
|
5.97
|
NA
|
NA
|
NA
|
NA
|
|
MYH6
|
rs365990*
|
14
|
23861811
|
G
|
0.364
|
0.3644
|
4.04E-10
|
0.78
|
rs365990
|
5.00E-45 [52]
|
1
|
1
|
|
-
|
rs148397504
|
20
|
5376623
|
A
|
0.001
|
0.0006
|
3.21E-09
|
18.54
|
NA
|
NA
|
NA
|
NA
|
- Summary of top hits of the imputed GWAS analysis of heart rate in 19,920 Generation Scotland participants, compared with associations reported in the GWAS catalogue. The starred (*) SNP indicates the same SNP in the GS and GWAS catalogue. Entries in bold are within 500,000 bases of a SNP that reached genome-wide significance in the genotyped GWAS analysis. Entries with missing GWAS catalogue top SNPs (indicated by NAs) are novel associations
