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Table 3 Heart rate top hits

From: Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

Gene

SNP

Chr

Position

Effect allele

GS minor allele frequency

HRC MAF

GS p value

GS effect size

GWAS catalog top SNP

GWAS catalog p value

GS and meta SNP R2

GS and meta SNP Dā€™

ICMT

rs9970334

1

6296238

G

0.447

0.4502

4.38E-08

0.70

rs846111

7.00E-40 [51]

0.47

0.98

-

rs755291044

3

87751558

A

0.002

-

1.80E-08

8.60

NA

NA

NA

NA

CSMD1

rs145669495

8

4102424

G

0.002

0.0024

2.01E-08

7.66

NA

NA

NA

NA

ASPH

rs142916219

8

62481520

G

0.004

0.0022

2.21E-08

5.97

NA

NA

NA

NA

MYH6

rs365990*

14

23861811

G

0.364

0.3644

4.04E-10

0.78

rs365990

5.00E-45 [52]

1

1

-

rs148397504

20

5376623

A

0.001

0.0006

3.21E-09

18.54

NA

NA

NA

NA

  1. Summary of top hits of the imputed GWAS analysis of heart rate in 19,920 Generation Scotland participants, compared with associations reported in the GWAS catalogue. The starred (*) SNP indicates the same SNP in the GS and GWAS catalogue. Entries in bold are within 500,000 bases of a SNP that reached genome-wide significance in the genotyped GWAS analysis. Entries with missing GWAS catalogue top SNPs (indicated by NAs) are novel associations