Fig. 7
From: Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis
IMQ treatment of MOLF males downregulates KC differentiation genes localized to suprabasal epidermis. a Suprabasal versus basal epidermis (GSE42114; sliding window analysis). Genes were ranked based upon their IMQ response and windows of 100 genes were tested for enrichment in suprabasal epidermis (red, suprabasal-increased; blue, suprabasal-decreased). b Human epidermal regeneration (GSE52651; sliding window analysis). Genes were ranked based upon their IMQ response and windows of 100 genes were tested for enrichment in regenerated epidermis (day 7 versus day 0; red, differentiation-increased; blue, differentiation-decreased). c Suprabasal versus basal epidermis. Enrichment statistics in MOLF and B6 males. d Human epidermal regeneration (day 7 versus day 0). Enrichment statistics in MOLF and B6 males. e, f Gene set enrichment analysis for the top 100 IMQ-decreased genes in MOLF males (e) and B6 males (f). Cumulative overlap (vertical axis) is shown between IMQ-decreased genes and genes ranked according to their expression in suprabasal versus basal epidermis (horizontal axis). g, h Genes most strongly elevated in suprabasal (g) versus basal (h) epidermis and in regenerated epidermis (day 7 versus day 0 cultures). F female, FC fold change, M male, PN uninvolved skin from psoriasis patients, PP lesional skin from psoriasis patients