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Fig. 5 | Genome Medicine

Fig. 5

From: A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

Fig. 5

Evidence for alternative activation of MØs in SSc-PF lung that is distinct from SSc skin. a Genes identified by differential network analysis and inferred to be indicative of lung-resident MØs are correlated with canonical markers of alternatively activated MØs such as CCL18 and CD163 in the Christmann dataset. b Summarized expression values (mean standardized expression value) of gene sets (coexpression modules) upregulated in various MØ states from the Christmann and Hinchcliff datasets: module CL1, classic activation (IFN-γ); modules ALT 1 and 2, alternative activation (IL-4, IL-13); modules FFA 1, 2, and 3, treatment with free fatty acids. FFA free fatty acid. Modules from [34]. Asterisks (*) indicate significant differences (p < 0.05)

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Genome Medicine

ISSN: 1756-994X

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