A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

Table 4 Selected pathways that are similar to overlapping coexpression patterns in consensus clusters in the information graph

Consensus cluster	Summary of selected pathways
1A	DNA repair Cell cycle RNA metabolism Transcription
2	Cell–cell junction organization Aquaporin-mediated transport Tight junctions
3A	Endocytosis mRNA processing Metabolism of proteins
4A	T cytotoxic and helper pathway Antigen processing and presentation Allograft rejection
4B	ECM receptor interaction Collagen formation ECM organization TGF-beta signaling Signaling by PDGF
5	G2 M checkpoint Unwinding of DNA Cell cycle
6	Notch signaling Nuclear receptors in lipid metabolism and toxicity
7	Steroid biosynthesis Fatty acid metabolism PPAR signaling pathway
8	Keratin metabolism FGFR ligand binding and activation

We calculated the Jaccard similarity index between edges in the information graph and canonical pathways and used a Mann–Whitney U test to assess whether a particular pathway was more similar to edges within a consensus cluster than outside the consensus cluster

ISSN: 1756-994X