Fig. 3

Relationship between complex diseases/traits and AMD based on significant genetic score associations. Nodes represent diseases or traits and are colored according to uniform color scheme (see also Fig. 2 and Additional file 2: Table S1). The size of each node represents the effect size of the association with AMD. Diseases and traits within distinct disease categories (see also Fig. 2) are connected with lines colored according to the respective disease category. Lines connecting AMD and diseases/traits indicate the direction of the association with red lines indicating an adverse association and blue lines representing protective associations. Gray lines depict interactions according to literature which could not be confirmed by genetic scores or were not investigated within this study. The numbers in brackets indicate the references which either support or dispute the respective interaction. The colors of the numbers indicate whether the cited literature reported an adverse (red) or a protective (blue) interaction. In case a finding is novel, no literature reference is presented on a connection between nodes