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Table 1 Patient characteristics of the head and neck cancers for which DNA methylome data were analysed

From: Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

Patient characteristics HPV positive No. cases (%)a HPV negative No. cases (%)a
Pooled cases 66 (100) 272 (100)
 TCGA 36 (54.5) 242 (89.0)
 UCL 24 (21 FFPE) (36.4) 24 (21 FFPE (8.8)
 FITMANET 6 (9.1) 6 (2.2)
Male 55 (83.3) 195 (71.7)
Female 11 (17.7) 77 (28.3)
Median age (range) 59 (35–86) 62 (19–90)
Tobacco smoking
 Never/light smokers 17 (25.7) 54 (19.8)
 Smokers 25 (37.9) 218 (80.0)
 Not available 24 (36.4) 25 (9.2)
Alcohol consumption
 No 9 (13.6) 83 (30.5)
 Yes 32 (48.5) 159 (58.5)
 Not available 25 (37.9) 30 (11.0)
Tumour stage
 T1 8 (12.1) 13 (4.8)
 T2 19 (28.8) 49 (18.0)
 T3 9 (13.6) 64 (23.5)
 T4 (A + B) 28 (42.4) 118 (43.4)
 Not available 2 (3.1) 28 (10.3)
Tumour site
 Oral cavity 12 (18.2)b 162 (59.5)
 Oropharynx 51 (77.3)c 35 (12.9)
 Neck (hypopharynx and larynx) 3 (4.5)d 75 (27.6)
  1. aPercentage calculated using the total number of cases in the group of reference
  2. bHPV16: 8 cases, HPV33: 4 cases
  3. cHPV16: 48 cases, HPV33: 3 cases (1 co-infection with HPV16), HPV35: 1 case
  4. dHPV16: 3 cases (2 cases in hypopharynx, 1 case in larynx)