Fig. 1
From: Integrated genomic analysis of mitochondrial RNA processing in human cancers
Methylation differences between paired tumor and normal samples at tRNA p9 sites within mitochondrial tRNAs. a Number of normal–tumor pairs for each cancer type, including breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), stomach adenocarcinoma (STAD) and thyroid carcinoma (THCA). b Observed methylation levels for all 11 p9 sites within KIRC, split into normal and tumor. A similar plot showing all data points is shown in Additional file 1: Figure S1. c Standardized methylation levels split into normal and tumor for all cancers combined for p9 sites 1610, 5520, and 7526. d Two-way hierarchical clustering of mean standardized methylation levels of all 11 p9 sites for both normal and tumor samples across all cancer types