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Fig. 1 | Genome Medicine

Fig. 1

From: Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Fig. 1

High-level overview for probing growth factor receptor networks in breast cancer. a Overexpression of growth factor receptor network (GFRN) genes in human mammary epithelial cells (HMECs): AKT, BAD, EGFR, HER2, IGF1R, RAF1, and KRAS (G12V). b Generation of RNA-sequencing data from HMECs overexpressing GFRN genes and signature generation using ASSIGN. c Determination of GFRN pathways activation across TCGA breast tumors and ICBP breast cancer cell lines and identification of novel phenotypes based on GFRN activity. d Linking novel phenotypes to survival and drug response mechanisms in biochemical and drug response assay

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