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Fig. 7 | Genome Medicine

Fig. 7

From: Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Fig. 7

Summary of the survival and growth phenotypes in breast cancer. The survival phenotype is characterized by high HER2, IGF1R, and AKT pathway activation, high expression of pro-apoptotic BIM, low expression of anti-apoptotic MCL-1, and response to HER2, AKT, PI3K, and mTOR inhibitors. The growth phenotype is characterized by high EGFR, KRAS, and RAF1 activation, high expression of MCL-1, low expression of BIM, and response to EGFR/MEK-targeted therapies and chemotherapies

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Genome Medicine

ISSN: 1756-994X

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