Fig. 1

High similarity between the inherent transcriptional profiles associated with obesity and T2D. a The factorial design used to study T2D and obesity. Each group consists of three females and three males. b Muscle precursor cells were isolated from the subjects and differentiated in vitro. The cells were stimulated with insulin and samples for RNA-seq were taken at 0, 0.5, 1, and 2 h after stimulation in order to detect inherent transcriptional profiles associated with the four groups. c Heatmap of the fold changes for genes that were significant in at least one of the three groups compared to controls. Values are hierarchically clustered (dendrogram not shown), displaying the high consistency between the transcriptional signatures of the T2D, OB, and T2D&OB groups. (See also Additional file 5: Figure S1 and Additional file 6: Figure S2)