Fig. 1
From: GLADIATOR: a global approach for elucidating disease modules
The algorithmic pipeline. Known disease-related proteins (KnownDisPS) are projected into the PPI network. The largest connected component (LCC) is obtained for each disease. A simulated annealing procedure simultaneously expands all LCCs to disease modules while minimizing the squared Euclidean distance between the module-based similarities of the diseases to a given phenotypic-based similarity