Fig. 7

Distribution of shared and private VAFs for patient PG004. In the left plot, all putative mutations are displayed as SCC VAF versus dysplasia VAF. Private mutations are on the axes at x = 0 or y = 0. To make the distributions of VAFs more visible, they are displayed as histograms in the right plots. On the left, the distribution of dysplasia VAFs is shown, with the shared mutations in red. On the right the SCC VAFs are shown. Many patients had high numbers of putative calls with very low VAFs, which may be spurious and which make the rest of the distribution difficult to see. Therefore, the bottom two plots replicate the top plots, but only with VAFs >0.12. For each histogram, the p value showing the likelihood of the shared and total distributions being the same is shown