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Fig. 1 | Genome Medicine

Fig. 1

From: DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis

Fig. 1

Schematic illustrating the overall analysis procedure, using three input datasets: a PRAD and normal prostate tissue DNA methylation data from The Cancer Genome Atlas (TCGA); b transcription factor (TF) DNA binding profiles from Encyclopedia of DNA Elements (ENCODE) ChIP-seq experiments; c PRAD and normal prostate tissue gene expression data from TCGA. Analytical steps are numbered (ivii), with the final intersection between lists of TFs from steps (iii) and (vii) giving our candidate driver TFs

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