Fig. 1
From: Strength of functional signature correlates with effect size in autism
Functional convergence trend calculation. a Starting with disease gene set collections, we rank each by the average effect size of the genes within that set. b We then run “functional tests” on these genes sets and calculate a functional convergence for each. c Then, using the ranking of the disease gene sets, we measure the functional convergence signature—the correlation of the trend line of the functional convergences versus the rank