Fig. 3

Antimicrobial resistance genes present in LTCF ST131 isolates and results of mapping to plasmid pEK499. Mid-point rooted maximum likelihood tree based on the core genome of 297 ST131 isolates from 17 participants and the reference E. coli NCTC13441 genome after removal of MGEs and recombination events. The first vertical coloured column links genomes to study participant. Antimicrobial resistance genes are shown as black (present) or white (absent). blaOXA1 beta-lactam, aac-(6’)-Ib-cr aminoglycoside, mphA macrolide dfrA17 trimethoprim, tetA tetracycline, sul1/sul2 sulphonamide, strA/strB streptomycin resistance genes. Fragments of the pEK499 plasmid that are shared with a corresponding isolate are shown as red horizontal blocks. The bla _CTX-M-15 cassette (the bla _CTX-M-15 gene together with the flanking IS elements) is highlighted in dark blue