a Histograms of case versus control differential expression (DESeq2 p values) for AnCg (red), DLPFC (blue), and nAcc (green) in each disorder. A minimum DESeq2 base mean of 10 was required for inclusion. b Pairwise Spearman correlations of log2 fold gene expression changes between each disorder and CTL in each brain region. Circle sizes are scaled to reflect absolute Spearman correlations. c Venn diagram showing overlap of genes differentially expressed between SZ (red), BPD (blue), and MDD (green) versus CTL at p value <0.05 in the AnCg. d Log2 fold expression change correlation of 87 genes with FDR <0.05 comparing SZ and CTL (AnCg) in the Pritzker dataset with the SNCID dataset (Spearman coefficient = 0.812, p value <0.0001). Genes differentially expressed at a FDR <0.05 in both cohorts are identified with red circles. e Hierarchical clustering of 27 SZ and 26 CTL tissues in the SNCID dataset using variance-stabilized expression of 1003 genes differentially expressed between SZ and CTL in the AnCg (uncorrected p value <0.05) in the Pritzker dataset. CTL (black), SZ (red), lowly expressed genes (blue pixels), highly expressed genes (yellow pixels).