TY - JOUR AU - Nicol, Dianne AU - Eckstein, Lisa AU - Morrison, Michael AU - Sherkow, Jacob S. AU - Otlowski, Margaret AU - Whitton, Tess AU - Bubela, Tania AU - Burdon, Kathryn P. AU - Chalmers, Don AU - Chan, Sarah AU - Charlesworth, Jac AU - Critchley, Christine AU - Crossley, Merlin AU - de Lacey, Sheryl AU - Dickinson, Joanne L. AU - Hewitt, Alex W. AU - Kamens, Joanne AU - Kato, Kazuto AU - Kleiderman, Erika AU - Kodama, Satoshi AU - Liddicoat, John AU - Mackey, David A. AU - Newson, Ainsley J. AU - Nielsen, Jane AU - Wagner, Jennifer K. AU - McWhirter, Rebekah E. PY - 2017 DA - 2017/09/25 TI - Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic JO - Genome Medicine SP - 85 VL - 9 IS - 1 AB - Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. SN - 1756-994X UR - https://doi.org/10.1186/s13073-017-0475-4 DO - 10.1186/s13073-017-0475-4 ID - Nicol2017 ER -