Table 1 Frequent gene alterations in 207 Japanese gastric cancers
From: Actionable gene-based classification toward precision medicine in gastric cancer
Number | Mutation gene | Frequency | SCNA gene | Alteration | Frequency |
|---|---|---|---|---|---|
1 | TP53 | 53.1% | ERBB2 | AMP | 12.1% |
2 | ARID1A | 15.9% | CCNE1 | AMP | 6.8% |
3 | CDH1 | 14.0% | KRAS | AMP | 5.8% |
4 | BRCA2 | 10.6% | ZNF217 | AMP | 5.8% |
5 | ARID1B | 10.1% | CDKN2A | DEL | 5.3% |
6 | ATM | 9.7% | CDKN2B | DEL | 5.3% |
7 | PIK3CA | 8.7% | GATA4 | AMP | 4.3% |
8 | APC | 8.2% | MYC | AMP | 2.4% |
9 | ACVR2A | 7.2% | CCND3 | AMP | 1.9% |
10 | CHD2 | 6.3% | CD274 | AMP | 1.9% |
11 | KMT2D | 6.3% | CDK6 | AMP | 1.9% |
12 | RNF43 | 5.8% | EGFR | AMP | 1.9% |
13 | EPHA2 | 5.8% | FGFR2 | AMP | 1.9% |
14 | TGFBR2 | 5.3% | JAK2 | AMP | 1.9% |
15 | FLCN | 4.3% | GNAS | AMP | 1.9% |
16 | PALB2 | 4.3% | CCND1 | AMP | 1.4% |
17 | PTPRT | 4.3% | MET | AMP | 1.4% |
18 | RAD50 | 4.3% | HSP90AB1 | AMP | 1.4% |
19 | BRCA1 | 3.9% | SMAD4 | DEL | 1.4% |
20 | STK11 | 3.9% | TEK | DEL | 1.4% |