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Table 1 Frequent gene alterations in 207 Japanese gastric cancers

From: Actionable gene-based classification toward precision medicine in gastric cancer

Number Mutation gene Frequency SCNA gene Alteration Frequency
1 TP53 53.1% ERBB2 AMP 12.1%
2 ARID1A 15.9% CCNE1 AMP 6.8%
3 CDH1 14.0% KRAS AMP 5.8%
4 BRCA2 10.6% ZNF217 AMP 5.8%
5 ARID1B 10.1% CDKN2A DEL 5.3%
6 ATM 9.7% CDKN2B DEL 5.3%
7 PIK3CA 8.7% GATA4 AMP 4.3%
8 APC 8.2% MYC AMP 2.4%
9 ACVR2A 7.2% CCND3 AMP 1.9%
10 CHD2 6.3% CD274 AMP 1.9%
11 KMT2D 6.3% CDK6 AMP 1.9%
12 RNF43 5.8% EGFR AMP 1.9%
13 EPHA2 5.8% FGFR2 AMP 1.9%
14 TGFBR2 5.3% JAK2 AMP 1.9%
15 FLCN 4.3% GNAS AMP 1.9%
16 PALB2 4.3% CCND1 AMP 1.4%
17 PTPRT 4.3% MET AMP 1.4%
18 RAD50 4.3% HSP90AB1 AMP 1.4%
19 BRCA1 3.9% SMAD4 DEL 1.4%
20 STK11 3.9% TEK DEL 1.4%
  1. AMP amplification, DEL deletion, SCNA somatic copy number alteration
  2. Bold gene symbols indicate genes from the 69 actionable genes for FDA-approved targeted therapies