Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

Table 3 Mayo Clinic Brain RNAseq data for SAR1A and RAB10 genes in AD vs. control brains

Gene ID	Chr	Start	Stop	Coding length	Tissue	Model	Comparison	Dx.Beta	EffectDirection	Dx.SE	Dx.pValue	Dx.qValue
RAB10	chr2	26256976	26360323	3631	TCX	Compre	Control_vs_AD	0.14	UpInAD	0.04	1.55E-03	7.12E-02
RAB10	chr2	26256976	26360323	3631	TCX	Simple	Control_vs_AD	0.32	UpInAD	0.05	6.96E-09	1.50E-06
SAR1A	chr10	71907045	71930279	6914	TCX	Compre	Control_vs_AD	-0.12	DownInAD	0.05	1.27E-02	1.80E-01
SAR1A	chr10	71907045	71930279	6914	TCX	Simple	Control_vs_AD	-0.10	DownInAD	0.04	2.07E-02	5.12E-02

Gene ID, ENSEMBL gene ID; Tissue, TCX temporal cortex; Dx.Beta, coefficient of effect in AD in comparison to controls; Dx.SE, standard error of effect; Dx.pValue, significance of effect (uncorrected); Dx.qValue, significance corrected using FDR-based q-values

ISSN: 1756-994X