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Table 4 Impact of RAB10 over-expression and knockdown in N2A695 cells

From: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

   p value Fold change (± SEM)
RAB10 over-expression Aβ40 0.0011 −0.5933 ± 0.1162
Aβ42 0.2008 0.3249 ± 0.3709
Aβ42/Aβ40 0.0133 2.014 ± 0.6894
sAPPalpha 0.3436 0.02252 ± 0.05198
sAPPbeta 0.0187 0.1466 ± 0.04776
sAPPtotal 0.3581 −0.01433 ± 0.03673
RAB10 knockdown Aβ40 0.4095 −0.06635 ± 0.2825
Aβ42 0.0003 −0.4453 ± 0.08428
Aβ42/Aβ40 0.0001 −0.3876 ± 0.02243
sAPPalpha 0.2899 0.1131 ± 0.188
sAPPbeta 0.2025 0.2457 ± 0.2642
sAPPtotal 0.3233 0.1446 ± 0.2922
  1. The p value for the comparison to GFP control (over-expression) and scrambled shRNA (knockdown) and fold change for each amyloid measurement are provided